ABSTRACT
Rendu-Osler-Weber Syndrome also known as Hereditary Hemorrhagic Telangiectasia is a rare systemic fibrovascular dysplasia, with dominant autosomal inheritance. It is characterized by recurrent epistaxis, mucocutaneous telangiectasia, visceral arteriovenous malformation and positive family history. There may be hematologic, neurologic, dermatologic and gastrointestinal complications. Therapy is supportive and aimed at preventing complications. In this article we report a case of Rendu-Osler-Weber in a 64 year-old man, with history of mucocutaneous telangiectasia since the third decade of life, recurrent epistaxis, positive family history and vascular ectasia in the gastrointestinal tract.
Subject(s)
Humans , Male , Middle Aged , Telangiectasia, Hereditary Hemorrhagic/pathology , Tongue Diseases/pathology , Syndrome , Telangiectasia, Hereditary Hemorrhagic/complications , Endothelial Cells/pathologyABSTRACT
Epidermodysplasia Verruciformis is a genodermatosis characterized by susceptibility to infection by specific HPV types (HPV 3/10 and beta-HPVs). It is considered to be the first model in human carcinogenesis induced by HPV. In this report we present a rare case of Epidermodysplasia Verruciformis associated with vertical transmission of HIV. Although most patients with HIV present infections by HPV virus, the frequency of Epidermodysplasia Verruciformis is no greater in patients with HIV because in EV there is a deficiency of specific cellular immunity to infection by some types of HPV, called HPV-related Epidermodysplasia Verruciformis.
A Epidermodisplasia Verruciforme é uma genodermatose que se caracteriza pela susceptibilidade à infecção por tipos específicos de HPV (HPVs 3 e 10 e os beta-HPVs) e é considerada o primeiro modelo no homem de carcinogênese induzida pelo HPV. Neste artigo apresenta-se um caso raro de Epidermodisplasia Verruciforme em um paciente com HIV desde o nascimento. Apesar dos doentes com HIV apresentarem mais infecções pelos vírus HPVs, existem poucos relatos na literatura de Epidermodisplasia Verruciforme no doente com HIV. Isso se explica, pois a Epidermodisplasia Verruciforme é consequência de uma deficiência celular específica à infecção por alguns tipos distintos de HPVs, ditos HPVs relacionados a Epidermodisplasia Verruciforme.
Subject(s)
Humans , Male , Young Adult , Epidermodysplasia Verruciformis/pathology , HIV Infections/complications , Epidermodysplasia Verruciformis/etiology , Skin/pathologyABSTRACT
O pênfigo vulgar é doença grave, que se caracteriza pelo aparecimento de bolhas e erosões mucocutâneas, tratadas sistêmica e topicamente. Alguns pacientes apresentam no tegumento lesões resistentes às terapias disponíveis. A hidrofibra com prata é curativo retentor e umidificador com amplo espectro bacteriano eficaz no tratamento de feridas e doenças bolhosas. Relata-se caso de PV com lesões na face e na região cervical que, tratado com curativo de hidrofibra com prata, apresentou melhora das lesões em dez dias.
Pemphigus vulgaris is a serious condition characterized by blisters and mucocutaneous erosions, which is treated systemically and topically. Some affected patients present lesions in the integument that are resistant to available therapies. Hydrofiber with silver is a retainer and humidifier dressing with broad bacterial spectrum, which is effective in treating wounds and bullous diseases. The authors describe a case of Pemphigus vulgaris with lesions on the face and neck that was treated with hydrofiber with silver dressing. There was an improvement in the lesions within 10 days.
ABSTRACT
A balanite de Zoon é lesão inflamatória benigna crônica, de etiologia desconhecida. Relata-se o caso de paciente do sexo masculino de 66 anos, há dois anos com placa eritematosa localizada na glande. Observou-se redução significativa do tamanho da placa e melhora do prurido com o uso de laser fracionado de CO2 associado ao ácido fusídico. O tratamento mostrou-se tolerável e de fácil execução. Concluímos que a lesão foi pouco responsiva ao tratamento tópico conservador com corticoide e muito mais responsiva ao tratamento com laser fracionado de CO2, obtendo-se boa resposta e melhora na qualidade de vida do paciente.
Zoon's balanitis is a benign chronic inflammatory lesion of unknown etiology. This article reports the case of a 66-year-old male patient who presented a 2-year history of a erythematous plaque located on the glans penis. The lesion had not been very responsive to conservative topical treatment with corticoid. A significant reduction in the plaque's size and an improvement in the pruritus was observed with the use of fractional CO2 laser combined with fusidic acid. The treatment was well tolerated and easy to carry out, and improved the patient's quality of life.